Alan Patrick Kypson, MD
Division of Cardiothoracic Surgery
Brody School of Medicine at East Carolina University
600 Moye Boulevard
Edward Nelson Warren Life Sciences Building Room # LSB 177
Greenville, NC 27834
FAX: 252.744.3618
Telephone:252.744.3552
kypsona@ecu.edu
EDUCATION
1981-5 Great Neck North Senior High School Diploma
Great Neck, NY
1985-9 Columbia College BA, History
New York City, NY
1989-93 Columbia College of Physicians&Surgeons MD
New York City, NY
PROFESSIONAL TRAINING
1984-8 Cardiovascular Surgical Assistant
Division of Cardiothoracic Surgery,
University Hospital of Zurich, Zurich, Switzerland.
1988-9 Emergency Medical Technician
New York, N.Y.
1988-90 Laboratory Research Assistant
Department of Anesthesiology,
Columbia College of Physicians&Surgeons,
New York, N.Y.
1993-4 Intern
Department of General Surgery,
Duke University Medical Center,
Durham, N.C.
1994-5 Junior Assistant Resident
Department of General Surgery,
Duke University Medical Center,
Durham, N.C.
1995-7 Research Fellow
Division of Cardiothoracic Surgery,
Duke University Medical Center,
Durham, N.C.
1996-7 Instructor in Surgery and Course Director
Physician Assistant Program,
Department of Surgery,
Duke University Medical Center,
Durham, N.C.
1997-9 Senior Assistant Resident
Department of General Surgery,
Duke University Medical Center,
Durham, N.C.
1999-2000 Chief Resident
Department of General Surgery,
Duke University Medical Center,
Durham, N.C.
2000-2 Cardiothoracic Surgery Resident
Division of Thoracic Surgery
Duke University Medical Center,
Durham, N.C.
HONORS and AWARDS
1994 First Place, National Board of Surgery, In-Service Examination,
Duke University Medical Center.
1995-7 NIH National Research Service Award IF32HL09303
“Cardiac Mechanics in Pressure-Overload Heart Failure.”
1998 Pilling Weck Award for Excellence in Clinical and Traditional
Science, “Myocardial Gene Transfer Enhances Function of the
Transplanted Heart.”
2004 American College of Cardiology Foundation/Pfizer Visiting
Professorship in Cardiovascular Medicine for R.C.J. Chiu, MD, PhD,
“Myocardial Stem Cell Transplantation”
2005 William E. Laupus Library Faculty Author Recognition Award
2006 Best Drawing Board Invention, “Cell Therapy Infusion Device,”
9th Annual NewEra Cardiac Care Meeting.
LISCENSURE
1994 Diplomate, National Board of Medical Examiners #424091
1997 North Carolina Medical License #97-01444
2001 Diplomate, American Board of Surgery #46728
2003 Diplomate, American Board of Thoracic Surgery #6806
SOCIETIES
2000-Present Member, Sabiston Surgical Society
2002-Present Member, North Carolina Medical Society
2003-Present Member, Association for Academic Surgery
2004-Present Member, Southern Thoracic Surgical Association
2004-Present Fellow, American College of Chest Physicians
2004-Present Member, Society of Thoracic Surgeons
2004-Present Fellow, American College of Surgeons
2004-Present Fellow, American College of Cardiology
2005-Present Member, Cardiac Surgery Biology Club
2005-Present Member, North Carolina Chapter, American College of
Surgeons
LANGUAGES
Czech (fluent), French, Spanish
ABSTRACTS
1. Nahas, G., Trouve, R., Manger, W., Kypson, A. Cocaine,
catecholamines and calcium homeostasis, The Physiologist 32:172,
1989.
2. Trouve, R., Nahas, G., Kypson, A. Angiotensin II and cocaine
lethal intoxication. FASEB Journal Volume 3, No.3, Part I, 1989.
3. Trouve, R., Kypson, A., Latour C., Nahas, G. Cocaine blunts the
baroreceptor reflex in rats. European Journal of Clinical
Pharmacology Volume 36, Sup I, 1989.
4. Trouve, R., Kypson, A., Sitbon, M., Latour, C., Nahas, G.
Intoxication grave par amphetamine: une nouvelle approche. Journal
of Toxicology and Clinical Experimentation Volume 9(3), p210. 1989.
5. Trouve, R., Nahas, G., Manger, W., Kypson, A.
Anticatecholaminergic properties of cocaine antidotes. FASEB Journal
Volume 4, No.4, Part II, 1990.
6. Kypson, A.P., El-Shewy, H.M., Soloma, S.H., Abd-Alla, O., Lowe,
J.E., Abdel-aleem, S. Effects of chronic inhibition of fatty acid
oxidation on stress tolerance in the heart. Journal of Molecular and
Cellular Cardiology Volume 29, No.6, p. A192. 1997.
7. Channon, K.M., Kypson, A.P., Blazing, M.A., Daggett C.W., Koch,
W.J., George, S.F. In vivo pulmonary artery adenoviral gene transfer
of nitric oxide synthase enhances pulmonary nitric oxide production.
Heart Volume 77, Supp.I, p. P8. 1997.
8. Maurice, J.P., Kypson, A.P., Skaer, C.A., Koch, W.J. -adrenergic
signaling characteristics in an infarct heart model. Circulation
Volume 96, No.8, p. I-362. 1997.
9. Skaer, C.A., Akhter, S.A., Kypson, A.P., McDonald, P., Peppel,
K.C., Koch, W.J. Adenoviral-mediated -adrenergic rescue of failing
ventricular cardiomyocytes. Circulation Volume 96, No.8, p. I-483.
1997.
10. Kypson, A.P., Akhter, S.A., Peppel, K., Hendrickson, S.C.,
McDonald, P., Lilly, R.E., Glower, D.D., Lefkowitz, R.J., Koch, W.J.
Adenoviral-mediated gene transfer of the 2-adrenergic receptor
improves function of the transplanted rat heart. Circulation Volume
96, No.8, p. I-670. 1997.
11. Channon, K.M., Kypson, A.P., Daggett, C.W., Blazing, M.A., Koch,
W.J., George, S.F. Enhanced pulmonary nitric oxide production and
vasomotor function after in vivo pulmonary artery adenoviral gene
transfer of nitric oxide synthase. European Heart Journal Volume 18,
Supp.3, p.118. 1997.
12. St.Louis, J.D., Hendrickson, S.C., Kypson, A.P., Hughes, G.C.,
Coleman, R.E., Donavan, C.L., Degrado, T.R., Seabage, L.,
Abdel-aleem, S., Landolfo, K.P., Lowe, J.E. An experimental model of
myocardial hibernation. Journal of American College of Cardiology
Volume 31, No.2, p.409A. 1998.
13. Shah, A.S., Atkins, B.Z., Hata, J.A., Kypson, A.P., Walton, G.B.,
Sudarshen, S., Davis, J.W., Wolfe, W.G., Glower, D.D. Right
ventricular overload depresses ventricular performance and alters
global beta-adrenergic signaling. Circulation Volume 98, No.17, p.
I-554-5. 1998.
14. Hughes, G.C., Annex, B.H., Yin, B., Pippen, A.M., Lin, P.,
Kypson, A.P., Peters, K.G., Lowe, J.E., Landolfo, K.P.
Transmyocardial laser revascularization (TMR) limits in vivo
adenoviral-mediated gene transfer in porcine myocardium. Journal of
American College of Cardiology Volume 33, No.2, Supp.A, p.355A.
1999.
15. Tai, O.S., Shah, A.S., Kypson, A.P., Glower, D.D., Koch, W.J.
Brain death induces increased -adrenergic receptor (AR) kinase 1
expression in the heart. Circulation Volume 100, No.18, p. I-165.
1999.
16. Hughes, G.C., Baklanov, D.V., Annex, B.H., Biswas, S.S., Kypson,
A.P., Pippen, A.M., Yin, B., Donovan, C.L., Lowe, J.E., Landolfo,
K.P. Denervation is not the long-term mechanism of action of
transmyocardial laser revascularization. Circulation Volume 100,
No.18, p. I-249. 1999.
17. Shah, A.S., White, D.C., Baklanov, D., Lilly, R.E., Kypson, A.P.,
Glower, D.D., Koch, W.J. In vivo intracoronary delivery and
overexpression of a ARK inhibitor to the failing heart: prospects
for molecular ventricular assistance. Circulation Volume 100, No.18,
p. I-481. 1999.
18. Shah, A.S., Lilly, R.E., Kypson, A.P., Tai, O.S., Hata, J.A.,
Glower, D.D., Koch, W.J. In vivo intracoronary delivery to and
overexpression of the human β2-adrenergic receptor (β2-AR) in the
left ventricle. American Heart Association Scientific Conference on
Molecular, Cellular, and Integrated Physiological Approaches to the
Failing Heart. 1999.
19. Glower, D.D., Kypson, A.P. Port-access aortic and mitral valve
replacement. Cardiothoracic Techniques and Technologies Volume 7,
p.74. 2001.
20. Bolotin, G., Kypson, A.P., Nifong L.W., Chitwood Jr., W.R.
Video-assisted mitral valve repair and left atrial ablation through
a right mini-thoracotomy. Heart Surgery Forum Volume 6, No.2, p.105.
2003.
21. Kypson, A.P. Perfusion for robotic and minimally invasive
cardiac surgery. Heart Surgery Forum Volume 6, No.2, p.111-2. 2003.
22. Bolotin, G., Scott, W.W., Austin, T.C., Charland, P.J., Kypson,
A.P., Nifong, L.W., Reade, C.C., Chitwood Jr., W.R. Robotic
skeletonizing of the mammary artery: is it safe? Heart Surgery Forum
Volume 6, Supp.1, p. S39-40. 2003.
23. Bolotin, G., Shapira Y., Gotler Y., Frolkis I.V., Kypson, A.P.,
Nesher N., Chitwood Jr., W.R., Uretzky G. The potential advantage of
“no-touch” aortic technique in off-pump complete arterial
revascularization. Heart Surgery Forum Volume 6, Supp.1, p. S51.
2003.
24. Bolotin, G., Kypson, A.P., Chu, V., Nifong, W.L., Chitwood Jr.,
RW. Should a video-assisted mini-thoracotomy be the approach of
choice for re-operative mitral valve surgery? Society for Heart
Valve Disease 2003.
25. Reade, C.C., Bower, C.E., Schuler, C.M., Austin, T.C., Charland,
P.J., Sun, Y.S., Kypson, A.P., Nifong, L.W., Chitwood Jr., W.R.
Acute effects of suction retraction on atrial hemodynamics and
histology. Journal of the American College of Surgeons Volume 197,
No.3 (Supplement), p. S26. 2003.
26. Bolotin, G., Kypson, A.P., Nifong, L.W., Reade, C., Freund, Jr.,
W., Chitwood, Jr., W.R. Robotic-assisted mitral valve repair with
microwave atrial fibrillation ablations: early clinical results.
Journal of the American College of Surgeons Volume 197, No.3
(Supplement), p. S24. 2003.
27. Koutlas, T.C., Maziarz, D.M., Conquest, A.M., Williams, J.M.,
Scott, W.W., Kypson, A.P., Chitwood Jr., W.R. Clinical results using
the St. Jude medical “symmetry” aortic connector system in 400
coronary artery bypass patients. Journal of American College of
Cardiology Volume 43, No. 5, Supplement A, p. 273A. 2004.
28. Reade, C.C., Bower, C.E., Bailey, B.M., Maziarz, D.M., Kypson,
A.P., Nifong, L.W., Chitwood Jr., W.R. Learning curves associated
with robotic mitral valve repair. Heart Surgery Forum Volume 7,
No.4, p. E302. 2004.
29. Kypson, A.P. Perfusion for minimally invasive cardiac surgery.
Heart Surgery Forum Volume 7, No.4, p. E298-9. 2004.
30. Cook, RC, Nifong, LW, Charland, P, Enterkin, J, Kypson, AP,
Reade CC, Chitwood, WR, SHVD. Significant reduction in annuloplasty
time with the use of nitinol clips in robotically-assisted mitral
valve repair.
31. Cook, R.C., Nifong, L.W., Lashley, G.G., Duncan, R.A., Campbell,
J.A., Law, Y.B., Kypson, A.P., Chitwood Jr., W.R. Early experience
with echocardiographically-guided selection of annuloplasty band in
robotically-assisted mitral valve repair. New Era 2005.
32. Cook, R.C., Nifong, L.W., Kypson, A.P., Reade, C.C., Law, Y.B.,
Chitwood Jr., W.R. Bileaflet mitral repairs using robotic assistance
in patients with Barlow’s valves. New Era 2005.
33. Cook, R.C., Nifong, L.W., Kypson, A..P, Chitwood Jr., W.R.
Robotically-assisted repair of anterior mitral valve leaflet
prolapse. Society of Heart Valve Disease 2005.
34. Cook R.C., Nifong, L.W., Law, Y.B., Kypson, A.P., Chitwood Jr.,
W.R. Minimally-invasive cryo-maze for atrial fibrillation with and
without concomitant mitral regurgitation. Society of Heart Valve
Disease 2005.
35. Cook, R.C., Nifong, L.W., Lashley, G.G., Duncan, R.A., Campbell,
J.A., Law, Y.B., Kypson, A.P., Chitwood, Jr., W.R. Echocardiographic
measurements alone do not allow for accurate non-invasive selection
of annuloplasty band size in robotic mitral repair. Society of Heart
Valve Disease 2005.
36. Reade, C.C., Moten, S., Rodriguez, E., Kypson, A.P., Nifong, L.W.,
Chitwood Jr., W.R. Technical considerations in minimally invasive
cryo-ablation for lone atrial fibrillation. New Era Cardiac Care p.
45-6. 2006.
37. Moten, S.C., Rodriguez, E., Phade, S., Kypson, A.P., Nifong, L.W.,
Chitwood Jr., W.R. Minimally invasive cryo-maze procedure: results
for lone atrial fibrillation. New Era Cardiac Care p. 50-1. 2006.
38. Tyson H., Muller-Borer B., Cascio W., Chitwood Jr. W.R., Kypson
A.P. Cell therapy infusion device. New Era Cardiac Care p.55-6.
2006.
39. Kypson A. What is the best tissue valve? NewEra Cardiac Care
p.38. 2006.
40. Kypson A. Biventricular pacing: detailed review. NewEra Cardiac
Care p.60-61. 2006.
MANUSCRIPTS
1. Kypson, A.P., Akhter, S.A., Peppel, K., Lilly, R.E., Dolber, P.,
Glower, D.D., Lefkowitz, R.J., Koch, W.J. Global overexpression of
-adrenergic receptors in the myocardium via adenoviral-mediated
gene transfer. Surgical Forum Volume XLVII, p.282-4. 1996.
2. Lilly, R.E., Peppel, K., Kypson, A.P., Silvestry, S.C., Glower,
D.D., Koch, W.J., Lefkowitz, R.J. Intracoronary administration of
adenovirus for gene transfer into adult rabbit myocardium. Surgical
Forum Volume XLVII, p.279-281. 1996.
3. Sabiston Jr., D.C., Kypson, A.P., Friesinger, G.C. Severe
stenosis of the left main coronary artery with endarterectomy and
graft:33-year follow-up. Annals of Thoracic Surgery Volume 64, No.5,
p.1559-60. 1997.
4. Kypson, A.P., Daggett, C.W., Channon, K.M., Gullotto, C., George,
S.E., Koch, W.J. In vivo pulmonary adenoviral-mediated gene transfer
of nitric oxide synthase increases nitric oxide production. Surgical
Forum Volume XLVIII, p.333-5. 1997.
5. Kypson, A.P., Akhter, S.A., Skaer, C.A., McDonald, P.H., Peppel,
K.C., Glower, D.D., Lefkowitz, R.J., Koch, W.J. Restoration of
-adrenergic signaling in failing cardiac ventricular myocytes via
adenoviral-mediated gene transfer. Proceedings of the National
Academy of Sciences, USA. Volume 94, p.12100-5. 1997.
6. Kypson, A.P., Peppel, K., Akhter, S.A ., Lilly, R.E., Glower, D.D.,
Lefkowitz, R.J., Koch, W.J. Ex vivo adenoviral-mediated gene
transfer in the transplanted adult rat heart. Journal of Thoracic
and Cardiovascular Surgery Volume 115, No.3, p.623-30. 1998.
7. Shah, A.S., Hata, J.A., Kypson, A.P., Glower, D.D., Koch, W.J.
Adenoviral-mediated overexpression of the beta-adrenergic receptor
kinase inhibitor in a cardiac transplant model. Surgical Forum
Volume XLIX, p.278-9. 1998.
8. Hughes, G.C., Lowe, J.E., Kypson, A.P., St.Louis, J.D., Pippen,
A.M., Peters, K.G., Coleman, R.E., DeGrado, T.R., Donovan, C.L.,
Annex, B.H., Landolfo, K.P. Neovascularization after transmyocardial
laser revascularization in a model of chronic ischemia. Annals of
Thoracic Surgery Volume 66, No.6, p.2029-36. 1998.
9. Maurice, J.P, Shah, A., Kypson, A.P., Hata, J., White, D.C,
Glower, D.D., Koch, W.J. Molecular -adrenergic signaling
abnormalities in failing rabbit hearts after infarction. American
Journal of Physiology Volume 276, Issue 6, p. H1853-60. 1999.
10. Hughes, G.C., Kypson, A.P., St.Louis, J.D., Annex, B.H.,
Coleman, R.E., DeGrado, T.R., Donovan, C.L., Lowe, J.E., Landolfo,
K.P. Improved perfusion and contractile reserve after
transmyocardial laser revascularization in a model of hibernating
myocardium. Annals of Thoracic Surgery Volume 67, No.6, p.1714-20.
1999.
11. Kypson, A.P., Hendrickson, S.C., Akhter, S.A., Wilson, K.,
McDonald, P.H., Lilly, R.E., Dolber, P.C., Glower, D.D., Lefkowitz,
R.J., Koch, W.J. Adenoviral-mediated gene transfer of the 2
-adrenergic receptor enhances cardiac function. Gene Therapy Volume
6, No.7, p.1298-1304. 1999.
12. Hughes, G.C., Annex, B.H., Yin, B., Pippen, A.M., Lin, P.,
Kypson, A.P., Peters, K.G., Lowe, J.E., Landolfo, K.P.
Transmyocardial laser revascularization (TMR) limits in vivo
adenoviral-mediated gene transfer in porcine myocardium.
Cardiovascular Research Volume 44, No. 1, p. 81-90. 1999.
13. Shah, A.S., Lilly, R.E., Kypson, A.P., Tai, O., Hata, J.A.,
Baklanov, D., Glower, D.D., Koch, W.J. In vivo intracoronary
delivery to and overexpression of the human 2-adrenergic receptor
in the right ventricle: prospects for molecular right ventricular
assistance. Surgical Forum Volume L, p.119-20. 1999.
14. Hughes, G.C., Kypson, A.P., Yin, B., St.Louis, J.D., Biswass,
S.S., Annex, B.H., Coleman, R.E., DeGrado, T.R., Donovan, C.L.,
Landolfo, K.P., Lowe, J.E. Induction of angiogenesis following
transmyocardial laser revascularization in a model of chronic
ischemia: a comparison of holmium:YAG, carbon dioxide, and excimer
lasers. Surgical Forum Volume L, p.115-7. 1999.
15. Shah, A.S., Lilly, R.E., Kypson, A.P., Tai, O., Hata, J.A.,
Pippen, A., Silvestry, S.C., Lefkowitz, R.J., Glower, D.D., Koch,
W.J. Intracoronary delivery and overexpression of the 2-adrenergic
receptor in the heart: prospects for molecular VAD. Circulation
Volume 101, No.4, p.408-14. 2000.
16. St. Louis, J.D., Hughes, G.C., Kypson, A.P., DeGrado, T.R.,
Donovan, C.L., Coleman, R.E., Yin, B., Steenbergen, C., Landolfo,
K.P., Lowe, J.E. An experimental model of chronic myocardial
hibernation. Annals of Thoracic Surgery Volume 69, No.5, p.1351-57.
2000.
17. Shah, A.S., Atkins, B.Z., Hata, J.A., Tai, O., Kypson, A.P.,
Lilly, R.E., Davis, J.W., Koch, W.J., Glower, D.D. Early effects of
right ventricular volume overload on ventricular performance and
beta-adrenergic signaling. Journal of Thoracic and Cardiovascular
Surgery Volume 120, No.2, p.342-9. 2000.
18. Hughes, G.C., Kypson, A.P., Annex, B.H., Yin, B., St. Louis,
J.D., Biswas, S.S., Coleman, E., DeGrado, T.R., Donovan, C.L.,
Landolfo, K.P., Lowe, J.E. Induction of angiogenesis after TMR: a
comparison of holmium:YAG, CO2, and excimer lasers. Annals of
Thoracic Surgery Volume 70, No.2, p.504-9. 2000.
19. Shah, A.S., White, D.C., Tai, O., Hata, J.A., Wilson, K.H.,
Pippen, A., Kypson, A.P., Glower, D.D., Lefkowitz, R.J., Koch, W.J.
Adenovirus-mediated genetic manipulation of the myocardial
-adrenergic signaling system in transplanted hearts. Journal of
Thoracic and Cardiovascular Surgery Volume 120, No.3, p.581-8. 2000.
20. Kypson, A.P., Wentzensen, N., Georgiade, G.S., Vaslef, S.N.
Traumatic vertebrojugular arteriovenous fistula: a case report.
Journal of Trauma Volume 49, No.6, p.1141-3. 2000.
21. Shah, A.S., White, D.C., Emani, S., Kypson, A.P., Lilly, R.E.,
Wilson, K., Glower, D.D., Lefkowitz, R.J., Koch, W.J. In vivo
ventricular gene delivery of a -adrenergic receptor kinase
inhibitor to the failing heart reverses cardiac dysfunction.
Circulation Volume 103, No.9, p.1311-6. 2001.
22. Glower, D.D., Landolfo, K.P., Kypson, A.P., Bashore, T.M.,
Harrison, K., Wang, A., Warner, J.J. Is port-access applicable to
complex mitral valve repair? Heart Surgery Forum Volume 5, Supp.1,
p. S76-87. 2002.
23. Kypson, A.P., Glower, D.D. Port-access approach for combined
aortic and mitral valve surgery. Annals of Thoracic Surgery Volume
73, No.5, p. 1657-8. 2002.
24. Kypson, A.P., Glower, D.D. Minimally invasive tricuspid surgery
using port-access. Annals of Thoracic Surgery Volume 74, No.1, p.
43-5. 2002.
25. Kypson, A.P., Onaitis, M.W., Feldman, J.M., Tyler, D.S.
Carcinoid and chylous ascites: an unusual association. Journal of
Gastrointestinal Surgery Volume 6, No.5, p. 781-3. 2002.
26. Kypson, A.P., Warner, J.J., Telen, M.J., Milano, C.A. Paroxysmal
cold hemoglobinuria and cardiopulmonary bypass: a case report.
Annals of Thoracic Surgery Volume 75, No.2, p. 579-81. 2003.
27. Kypson, A.P., Morphew, E., Jones, R., Gottfried, M.R., Seigler,
H.F. Heterotopic ossification in rectal cancer: a rare finding with
a novel proposed mechanism. Journal of Surgical Oncology Volume 82,
No.2, p. 132-6. 2003.
28. Swaminathan, M., Kypson, A.P., Perna, J.G., Davis, R.D.,
Stafford-Smith, M. Right ventricular rupture during off pump
coronary bypass surgery. Journal of Cardiothoracic and Vascular
Anesthesiology Volume 17, No.1, p. 87-9. 2003.
29. Chitwood Jr., W.R., Kypson, A.P., Nifong, L.W. Robotic mitral
valve surgery: a technologic and economic revolution for heart
centers. American Heart Hospital Journal Volume 1, No.1, p.30-9.
2003.
30. Kypson, A.P., Nifong, L.W., Chitwood Jr., W.R. Robotic mitral
valve surgery. Seminars in Thoracic and Cardiovascular Surgery
Volume 15, No.2, p. 121-9. 2003.
31. Kypson, A.P., Nifong, L.W., Chitwood Jr., W.R. Robotic mitral
valve surgery. Surgical Clinics of North America Volume 83, No.6, p.
1387-1403. 2003.
32. Kypson, A.P., Nifong, L.W., Chitwood Jr., W.R. Robotic cardiac
surgery. Journal of Long-Term Effects of Medical Implants Volume 13,
No.6, p. 451-64. 2003.
33. Bolotin, G., Kypson, A.P., Nifong, L.W., Chitwood Jr., W.R. A
technique for evaluating competitive flow for intra-operative
decision making in coronary artery surgery. Annals of Thoracic
Surgery Volume 76, No.6, p.2118-20. 2003.
34. Bolotin, G., Kypson, A.P., Reade, C.C., Chu, V., Freund, W.L.,
Nifong, W.L., Chitwood Jr., RW. Should a video-assisted mini-thoracotomy
be the approach of choice for re-operative mitral valve surgery? The
Journal of Heart Valve Disease Volume 13, p.155-8. 2004.
35. Bolotin, G., Scott, W.W., Austin, T.C., Charland, P.J., Kypson,
A.P., Nifong, L.W., Salleng, K., Chitwood Jr., W.R. Robotic
skeletonizing of the internal thoracic artery: is it safe? Annals of
Thoracic Surgery Volume 77, No.4, p.1262-5. 2004.
36. Kypson, A.P., Felger, J.E., Nifong, L.W., Chitwood Jr., W.R.
Robotics in valvular surgery: 2003 and beyond. Current Opinion in
Cardiology Volume 19, No.2, p. 128-33. 2004.
37. Kypson, A.P., Nifong, L.W., Chitwood Jr., W.R. Robot-assisted
surgery: training and re-training surgeons. International Journal of
Medical Robotics and Computer Assisted Surgery Volume 1, No.1, p.
70-6. 2004.
38. Kypson, A.P., Chitwood Jr., W.R. Robotic applications in cardiac
surgery. International Journal of Advanced Robotic Systems Volume 1,
No 2, p. 87-92. 2004.
39. Kypson, A.P., Chitwood Jr., W.R. Robotic mitral valve surgery.
American Journal of Surgery Volume 188, No. 4S1, p. 83-8. 2004.
40. DeRose Jr., J.J., Kypson, A.P. Robotic arrhythmia surgery and
resynchronization. American Journal of Surgery Volume 188, No. 4S1,
p. 104-11. 2004.
41. Bolotin, G., Kypson, A.P., Nifong, L.W., Chitwood Jr., R.W.
Robotically-assisted left atrial fibrillation ablation and mitral
valve repair through a right mini-thoracotomy. Annals of Thoracic
Surgery Volume 78, No. 4, p.e63-4. 2004.
42. Khan, N.U., Lerrick, K.S., Kypson, A.P., Saha, P.K. Pitfalls of
coronary angiography in aortic dissection. International Journal of
Angiology Volume 13, p. 84-5. 2004.
43. Reade, C.C., Johnson, J.O., Bolotin, G., Freund Jr., W.L.,
Jenkins, N.L., Bower, C.E., Masroor, S., Kypson, A.P., Nifong, L.W.,
Chitwood Jr., W.R. Combining robotic mitral valve repair and
microwave atrial fibrillation ablation: techniques and initial
results. Annals of Thoracic Surgery Volume 79, p.480-4. 2005.
44. Kypson, A.P., Chitwood Jr., W.R. The use of robotics in
cardiovascular surgery. Future Cardiology Volume 1, No.1, p.61-7.
2005.
45. Kypson, A.P., Chitwood Jr., W.R. Robotically assisted cardiac
surgery. Indian Heart Journal Volume 56, No. 6, p.618-21. 2004.
46. Reade, C.C., Bower, C.E., Kypson, A.P., Nifong, L.W., Wooden,
W.A., Chitwood Jr., W.R. Re-examining contraindications for
minimally invasive mitral valve surgery. Heart Surgery Forum Volume
8, p. 39-41. 2004.
47. Kypson, A.P., Chitwood Jr., W.R. Palmar microcirculation
following harvesting of the radial artery in coronary
revascularization (Invited Commentary). Annals of Thoracic Surgery
Volume 79, No. 3, p.1030. 2005.
48. Kypson, A.P., Frazier, D.W., Moran, J.F. Internal mammary artery
injury following transvenous pacemaker implantation. Journal of
Thoracic and Cardiovascular Surgery Volume 129, No.3, p.677-8. 2005.
49. Reade, C.C., Bower, C.E., Bailey, B.M., Maziarz, D.M., Masroor,
S., Kypson, A.P., Nifong, L.W., Chitwood Jr, W.R. Robotic mitral
valve annuloplasty with double arm nitinol U-clips. Annals of
Thoracic Surgery Volume 79, No. 4, p.1372-6. 2005.
50. Kypson, A.P., Chitwood Jr., W.R. Early clinical results with a
magnetic connector for distal coronary artery anastomoses (Invited
Commentary). Annals of Thoracic Surgery Volume 79, No. 5, p. 1743.
2005.
51. Reade, C.C., Bower, C.E., Schuler, C.M., Austin, T.C., Charland,
P.J., Smith, N.L., Sun, Y.S., Nifong, L.W., Chitwood Jr., W.R.,
Kypson, A.P. Acute effects of suction retraction on atrial
hemodynamics and histology. Journal Thoracic and Cardiovascular
Surgery Volume 130, No. 1, p.114-9. 2005.
52. Reade, C.C., Kypson, A.P., Chitwood, W.R. 8th Annual NewEra
cardiac care: innovation and technology. Future Cardiology Volume 1,
No. 2, p. 157-9. 2005.
53. Kypson, A.P. Sudden cardiac arrest after coronary bypass
grafting secondary to massive carbon dioxide embolism. Journal of
Thoracic and Cardiovascular Surgery Volume 130, No. 3, p. 936-7.
2005.
54. Reade, C.C., Kypson, A.P., Williams, J.M. Valve sparing aortic
root replacement after prior Starr-Edwards aortic valve replacement.
The Journal of Heart Valve Disease Volume 14, No. 5, p. 695-6. 2005.
55. Kypson, AP, Reade, CC, Wood, W, Mohr, FW, Chitwood Jr., WR.
Robotically assisted repair of a papillary muscle injury due to
blunt trauma. Journal of Trauma (in press).
56. Rodriguez, E., Kypson, A.P., Moten, S.S., Nifong, L.W., Chitwood
Jr., W.R. Robotic mitral surgery at East Carolina University: A six
year experience. International Journal of Medical Robotics and
Computer Assisted Surgery (in press).
57. Tyson, GH, Parker, F, Goettler, C, Kypson, AP. Novel therapeutic
approaches to combined cardiac and aortic traumatic injuries.
Journal of Trauma (in press).
58. Kypson, AP, Chitwood Jr., WR. Robotic cardiovascular surgery.
Expert Review (in press).
VIDEOS
1. Kypson, A.P., Glower, D.D. Redo tricuspid operation using port
access. American College of Surgeons. 2001.
2. Kypson, A.P., Glower, D.D. Tricuspid repair using port access.
Southern Thoracic Surgical Association. 2001.
3. Chitwood, W.R., Nifong, L.W., Kypson, A.P., Bolotin, G., Bower,
C.E., Fuller, J.D. Robotic mitral valve repair. American College of
Surgeons. 2002.
4. Bolotin, G., Kypson, A.P., Nifong, L.W., Chitwood Jr., W.R.
Video-assisted mitral valve repair and left atrial ablation through
a right mini-thoracotomy. New Era Cardiac Care. 2003.
6. Reade, C.C., Bowyer, C.E., Kypson, A.P., Nifong, L.W., Chitwood
Jr., W.R. Combining robotic mitral valve repair and microwave atrial
fibrillation ablation. Southern Thoracic Surgical Association. 2003.
7. Reade, C.C., Bowyer, C.E., Bailey, B.M., Kypson, A.P., Nifong,
L.W., Chitwood Jr., W.R. Robotic mitral valve annuloplasty utilizing
double arm nitinol u-clips. Southern Thoracic Surgical Association.
2003.
8. Reade, C.C., Kypson, A.P., Cook, R.C., Nifong, L.W., Chitwood
Jr., W.R. Complex robotic mitral valve repair: the Barlow’s valve.
New Era Cardiac Care. 2005.
9. Reade, C.C., Cook, R.C., Moten, S., Kypson, A.P., Nifong, L.W.,
Chitwood Jr., W.R. Minimally invasive cryo-ablation for atrial
fibrillation. American College of Surgeons. 2005.
10. Reade, C.C., Moten, S., Rodriguez, E., Kypson, A.P., Nifong, L.W.,
Chitwood Jr., W.R. Technical considerations in minimally invasive
cryo-ablation for lone atrial fibrillation. New Era. 2006.
BOOK CHAPTERS
1. Kypson, A.P., Ludwig, K. Laparoscopic Colectomy and
Abdominoperineal Resection. In Atlas of Laparoscopic Surgery, 2nd
edition, Philadelphia, Appleton & Lange. pp. 12.1-12.13. 1999.
2. Kypson, A.P. Cardiopulmonary Resuscitation. In Surgical Intensive
Care Handbook of Duke University, 5th edition, St. Louis, Mosby. pp.
39-57. 2000.
3. Kypson, A.P., Chitwood Jr., W.R. Cardiopulmonary Bypass during
Port-Access™ and Robotic Surgery. In Techniques in Extracorporeal
Circulation, 4th edition, London, Arnold. pp. 298-314. 2004.
4. Kypson, A.P., Nifong L.W., Chitwood Jr., W.R. Telerobotic-assisted
cardiac valve surgery in Primer of Robotic and Telerobotic Surgery,
1rst edition, Philadelphia, Lippincott Williams& Wilkins. pp.
118-123. 2004.
5. Kypson, A.P., Nifong, L.W., Chitwood Jr., W.R. Robotic and novel
visualization systems in Sabiston & Spencer’s Surgery of the Chest,
7th edition, Philadelphia, Elsevier Saunders. pp. 1385-1396. 2005.
6. Kypson, A.P., Nifong, L.W., Chitwood Jr., W.R. Minimally invasive
cardiac surgery in Mastery of Endoscopic and Laparoscopic Surgery,
2nd edition, Philadelphia, Lippincott Williams& Wilkins. pp. 559-67.
2005.
7. Kypson, A.P., Nifong, L.W., Chitwood Jr., W.R. Mitral valve
repair- robotic minimally invasive in Mastery of Cardiothoracic
Surgery, 2nd edition, (in press).
8. Kypson, A.P., Nifong, L.W., Chitwood Jr., W.R. Robotic assisted
mitral valve repair in Washington Institute Manual (in press).
9. Chitwood Jr., W.R. Kypson, A.P. Evolving endoscopic and robotic
techniques in Mastery of Surgery, 5th edition (in press).
10. Moten, S, Kypson, A.P., Chitwood Jr., W.R. Use of robotics in
other surgical specialties. Robotics in Urologic Surgery
(submitted).
CLINICAL INVESTIGATIONS/GRANTS
1. Co-PI, Corgentech PREVENT IV Study (CGTOO3-04), “A phase III,
multi-center randomized, double-blind, placebo-controlled trial of
the ex vivo treatment with CGTOO3 of coronary vein grafts in
patients undergoing coronary artery bypass graft procedures.” 2002.
2. PI, HEMASEEL APR Study (BPL 100), “A phase III two-part,
randomized, comparative, multicenter study of HEMASEEL APR
manufactured at BPL to a control agent and to HEMASEEL APR
manufactured at Immuno AG.” 2003.
3. PI, TELFA AMD Island dressing, “Effects pm wound healing and
incidence of sternal wound infections in subjects who have undergone
cardiac surgical procedures requiring median sternotomy.” 2004.
4. PI, PRIMO-CABG II (#2003141), “A multicenter, randomized,
double-blind, parallel-group, placebo-controlled study of 2 mg/kg
bolus plus 24-hour 0.05 mg/kg/hr infusion of pexelizumab in patients
undergoing coronary artery bypass grafting with cardiopulmonary
bypass.” 2004.
5. PI, FREEDOM trial, “Future revascularization evaluation in
patients with diabetes mellitus: optimal management of multivessel
disease.” 2004. (submitted).
6. Co-PI, “Role of atrial GIRK channels in the altered cardiac
autonomic function associated with cigarette smoking.” Philip Morris
External Research Program. $672,571. 2004. (submitted)
7. PI, “A randomized, double-blind, placebo-controlled, parallel
group, multicenter, proof of concept clinical study of CTI-01 in
patients undergoing major cardiac surgery with cardiopulmonary
bypass.” 2005.
EDITORIAL BOARDS
1. Minimally Invasive Surgery Center, CTS Net
REVIEWER
1. American Heart Journal
2. Asian Cardiovascular and Thoracic Annals
3. Current Surgery
4. American College of Cardiology, Abstract Grader 2004
5.Journal of Thoracic and Cardiovascular Surgery
6. Science
PRESENTATIONS
1. 82nd Clinical Congress of the American College of Surgeons, San
Francisco, CA, October 9, 1996.
2. 77th Annual Meeting of the American Association for Thoracic
Surgery, Washington, D.C., May 7, 1997.
3. 83rd Clinical Congress of the American College of Surgeons,
Chicago, IL, October 15, 1997.
4. 70th Scientific Sessions of the American Heart Association,
Orlando, FL, November 12 , 1997.
5. 87th Clinical Congress of the American College of Surgeons, New
Orleans, LA, October 8, 2001.
6. 48th Annual Meeting of the Southern Thoracic Surgical
Association, San Antonio, TX, November 7, 2001.
7. 6th Annual NewEra Cardiac Care, “Perfusion for Robotic and
Minimally Invasive Cardiac Surgery” Dana Point, CA, January 3, 2003.
8. “Remote Access Perfusion Techniques for Minimally Invasive
Cardiac Surgery” San Diego, CA, January 30-1, 2003.
9. 7th Annual NewEra Cardiac Care, “Perfusion for Minimally Invasive
Cardiac Surgery” Dana Point, CA, January 10, 2004.
10. 53rd Annual Scientific Session, American College of Cardiology,
“Robotic Valvular Surgery” New Orleans, LA, March 9, 2004.
11. 2nd Congress of the Polish Society of Cardiothoracic Surgeons,
“Minimally Invasive Surgery of the Mitral Valve” Katowice, Poland,
May 13, 2004.
12. Carolina Valve Symposium, “Percutaneous Valve Technology”
Greenville, NC, September 28, 2004.
13. 2nd Annual Carolina Valve Symposium, “Percutaneous and
Trans-ventricular Valve Technology” Greenville, NC, May 3, 2005.
14. 11th Annual Eastern Regional Cardiovascular Conference,
“Cellular Therapy for Myocardial Regeneration” Greenville, NC,
October 26, 2005.
15. 9th Annual NewEra Cardiac Care, “What is the best tissue valve?”
Newport Beach, CA, January 7, 2006.
16. 9th Annual NewEra Cardiac Care, “Biventricular pacing: a
detailed review” Newport Beach, CA, January 8, 2006.
MODERATOR
1. Abstract Session, 6th Annual NewEra Cardiac Care Meeting, Dana
Point, CA. 2003.
2. Perfusion Mini-Symposium, 7th Annual NewEra Cardiac Care Meeting,
Dana Point, CA. 2004.
3. Video Session, 7th Annual NewEra Cardiac Care Meeting, Dana
Point, CA. 2004.
4. Meet the Experts, 53rd Annual Scientific Session, American
College of Cardiology, “Robotic Valvular Surgery” New Orleans, LA.
2004.
5. Carolina Valve Symposium, Greenville, NC. 2004.
6. 2nd Annual Valve Symposium, Greenville, NC. 2005.
7. Videofest and Bullet Abstracts, 9th Annual NewEra Cardiac Care
Meeting, Newport Beach, CA. 2006.
INTERNET PUBLICATIONS
1. Smith, P., Kypson, A.P. Rate-control versus conversion strategy
in postoperative atrial fibrillation: a prospective, randomized
pilot study. Review in CT Digest.Com Volume 3, No.4. p. 5. http://ctdigest.com/Apr01/Apr01.asp?rev=5
2. Reade, C.C., Bowyer, C.E., Kypson, A.P., Nifong, L.W., Chitwood
Jr., W.R. Combining robotic mitral valve repair and microwave atrial
fibrillation ablation. CTSnet (Motion Picture) http://www.ctsnet.org/realmedia/vidgal/vg2004_reade_robotic.ram
3. Reade, C.C., Bower, C.E., Bailey, B.M., Kypson, A.P., Nifong, L.W.,
Chitwood Jr., W.R. Robotic Mitral Valve Annuloplasty Utilizing
Double Arm Nitinol U-Clips. CTSnet (Motion Picture) rtsp://pune.medbiq.com/c1/STSA/Reade_MVR_2003.rm
4. Kypson, A.P., Nifong, L.W., Chitwood Jr., W.R. Robot-assisted
surgery: training and re-training surgeons. International Journal of
Medical Robotics and Computer Assisted Surgery. http://www.roboticpublications.com
5. Kypson, A.P. Minimally invasive cardiopulmonary bypass- oxymoron
or not? CTSnet. http://www.ctsnet.org/doc/9268
6. Kypson, A.P. Clinical experience with the mini-extracorporeal
circulation system: an evolution or revolution? CTSnet. http://www.ctsnet.org/doc/9468
7. Kypson, A.P. Endoscopic conduit harvesting. CTSnet.
8. Kypson, A.P. Cardiac surgery “mini” revolution. CTSnet.
http://www.ctsnet.org/sections/innovation/minimallyinvasive/articles/article-24.html
COMMITTEES
1. Length of Stay, Pitt County Memorial Hospital
2. Acute Chest Pain Unit, Eastern Carolina Cardiovascular Institute
3. Personnel Recruitment, Eastern Carolina Cardiovascular Institute
4. General Surgery Residency Applicant Interviewer, Brody School of
Medicine
5. Program Committee, American College of Surgeons, North Carolina
Chapter, 50th Annual Meeting
6. Director, Clinical Trials Advisory Committee, East Carolina Heart
Institute
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