 You Su
Sun, MD
Surgical Research Instructor
Mailing Address:
East Carolina University School of Medicine
Department of Surgery
Division of Cardiovascular Research
Greenville, NC 27858-4354
Current professional and academic appointments:
Research Instructor, Department of Surgery, ECU School of Medicine 1993
Undergraduate medical education:
Tianjin Medical College, Tianjin City, Peoples Republic of China MD 1969
Postgraduate medical education:
Tianjin Medical College Hospital Surgical Intern 1968-69
Surgical Resident 1969-79
Chief Resident, General Surgery 1980
Department of Surgery, Downstate Medical,Center, State University of New York, Brooklyn
Research Fellow 1982-85
Department of Surgery, ECU School of Medicine Cardiothoracic Research Fellow 1986-92
Special Interests:
regulation of glucose homeostasis in cardiopulmonary bypass patients
Research Interests:
Pathophysiology of ischemic responses in normal and abnormal (hypertrophied ventricle,
non-cardiac effects of cardiopulmonary bypass, including insuresponses, cerebrovascular
reperfusion injury and platelet dysfunction and mechanisms of vasoreactive and
hyperplastic changes in veins transplanted for use as coronary artery bypass grafts.
Techniques range from sterile, survival surgery of large animal models to molecular
analysis of biopsy material.
Research activities:
Efficacy of lyophiliced platelets in CPB USONR
Performance of cryopreserved allograft and xenograft vascular prosthetics Cryolife Inc.
Right heart assist device to support off pump cardiac
positioning A-Med Inc.
Publications:
Peer-reviewed publications
Sun YS, Lust RM, Rock DT, Call KD, Otaki M, Chitwood WR.
The importance of blood flow measurements in occlusive, anesthetized models of brain
death. J of Investigative Surg 1994;7:371.
Sun YS, Lust RM, Dennis KJ, Rock DT, Call KD, Chitwood
Wr. Development of a large animal model of multifactoral, diet-induced, acquired
cardiovascular risk. J of Investigative Surg 1994;7:370.
Wixon CL, Burnett CM, Lust RM Sun YS, Mann C, Chitwood
Wr. Continuous hypothermic retrograde cerebral perfusion improves cerebral post ischemic
reperfusion following circulatory arrest during aortic arch surgery. Surg Forum
1995;XLVI:277-80.
Lust RM, Sun YS, Rock DT, Chitwood Wr. Functional
ischemic preconditioning does not protect against reperfusion-induced fibrillation in
adjacent myocardial regions. J Molecular and Cellular Cardiol 1995;27:A30.
Sun YS, Lust RM, Dohm LG, Wixon CL, Dennis KJ, Chitwood
WR. Impaired glucose clearance/insulin resistance induced by cardiopulmonary bypass may be
caused by glucose transport protein (GLUT-4) loss. Surg Forum 1996;47:256-258.
Eskew TD, Ollerenshaw JD, Philpott JM, Dennis KJ, Dawson
P, Sun YS, Chitwood WR, Lust RM. Successful small diameter arterial grafting using
cryopreserved allograft arteries. ASAIO J 1997;43(5):M522-26.
Philpott JM, Eskew TD, Sun YS, et al. A paradox of
cerebral hyperperfusion in the face of cerebral hypotension: the effect of perfusion
pressure on cerebral blood flow and metabolism during normothermic cardiopulmonary bypass.
J Surg Research 1998;77(2):141-49.
Philpott JM, Eskew TD, Kim VB, Brown PM, Wixon CL,
Foreman BH, Fairbrother SN, Sun YS, et al. Chronic hypertension compromises cerebral blood
flow and metabolism in dogs during normothermic cardiopulmonary bypass. Circulation Suppl
1998;98(17):I-517.
Kim VB, Brown PM, Philpott JM, Eskew TD, Sun YS, et al.
Cerebral metabolism and vascular autoregulation are compromised during normothermic
cardiopulmonary bypass in dogs with severe carotid artery stenosis. Circulation Suppl
1998;98(17):I-685.
National/regional presentations
Sun YS, Lust RM, Dennis KJ, et al. Development of a large animal model of diet-induced
multifactorial, acquired cardiovascular risk. Academy of Surg Research, September 22,
1994.
Sun YS, Lust RM, Rock DT, et al. The importance of blood flow measurements in
occlusive, anesthetized animal models of brain death. Academy of Surg Research, September
22, 1994.
Wixon CL, Burnett CM, Lust RM, Sun YS, et al. Continuous hypothermic retrograde
cerebral perfusion improves cerebral post-ischemic reperfusion following circulatory
arrest during aortic arch surgery. 81st Congress of ACS, October, 1995.
Sun YS, Lust RM, Dohm LG, et al. Impaired glucose clearance/insulin resistance induced
by cardiopulmonary bypass may be caused by glucose transport protein (GLUT-4) loss. 82nd
Congress of the ACS, October, 1996.
Philpott JM, Eskew TD, Sun YS, et al. Effect of perfusion pressure on cerebral
metabolism during normothermic bypass. Assn for Academic Surgery, Dallas, TX, November,
1997.
Kim VB, Brown PM, Philpott JM, Sun YS, et al. Protecting the brain during
cardiopulmonary bypass: the continuing merits of hypothermia. Surgical Forum of ACS,
Orlando, FL, 1998.
Kim VB, Brown PM, Philpott JM, Eskeew TD, Sun YS, et al. Cerebral metabolism and
vascular autoregulation are compromised during normothermic cardiopulmonary bypass in dogs
with severe carotid artery stenosis. 71st Scientific Sessions of the American
Heart Assn, Dallas, TX, November, 1998.
McCotter C, Sun YS, Lust RM, et al. A simple in-line pulse wave device restores
pulsatile pressure during and baroreceptor control after cardiopulmonary bypass. ASAIO
Annual Meeting, San Diego, CA, June, 1999.
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