 |
Kathryn M. Verbanac
Professor of Surgery
Degrees and Designations: Ph.D.
Mailing Address:
East Carolina University
School of Medicine
Department of Surgery
Greenville, NC 27858-4354
|
Current professional and academic
appointments:
Associate Professor of Surgery, ECU School of Medicine 1996
Adjunct Appointments, Department of Microbiology & Immunology 1995
Department of Biology and Department of Physiology 1998
Undergraduate medical
education:
Kalamazoo College BA 1977
Postgraduate medical education:
Iowa State University MS 1977- 1979
University of Iowa Ph.D. 1986
Special Interests:
Detection of breast cancer micrometases, vascular endothelial cell biology, xenogeneic
immune responses, gene therapy
Research activities:
Polymerase Chain Reaction and the Detection of Breast Cancer
Metastases in Sentinel Lymph Nodes; (supported by the Department of Defense Breast Cancer
Research Program, Clinical Translational Research Grant and Career Development Award)
The role of vascular endothelium in cell-mediated
xenogeneic responses
Vascular endothelial cell homing to sites of
neoangiogenesis
The role of vascular endothelium in cell-mediated xenogenic responses
Vascular endothelial cell homing to sites of
neoangiogenesis
The role of anti-donor antibody and cytokine gene
polymorphisms in renal allograft rejection
Peer-Reviewed Publications:
Verbanac KM, Carver FM, Haisch CE, Thomas JM. A Role for Transforming Growth
Factor-Beta in the Veto Mechanism in Transplant Tolerance. Transplantation 1994;57:893-900.
Tafra, L, Lannin,D, Swanson, MS, VanEyk, J, Verbanac, KM, et al.
(2001) “Multicenter trial of sentinel node biopsy for breast
cancer using both technetium sulfur colloid and isosulfan blue
dye”, Annals of Surg 233(1):51-59.
Coleman TS, Pittman HK, Purser S, Haisch CE, Verbanac KM (2001)
“Human T cell - porcine endothelial cell interactions induce human
T1 cytokines and porcine activation markers”, Journal of Surgical
Research 97:184-191.
Verbanac KM. “Molecular Detection of Breast Cancer Markers”,
Invited Commentary, In Press, June 2001, Molecular Diagnosis.
Tafra L, Verbanac KM., Swanson MS and Lannin DR. (2001)
“Preoperative chemotherapy and sentinel lymphadenectomy for breast
cancer”, American Journal of Surgery 182:312-315.
Posekany K, Pittman HK, Bradfield JF, Haisch CE, Verbanac K.
(2002) “Induction of cytolytic anti-gal antibodies in alpha 1,3
galactosyltransferase gene knock-out mice by oral inoculation with
Escherichia coli 086.B7 bacteria” , Infection and Immunity
70(11):6215-6222.
Mannie A, Min C, Fleming T, Tafra L, Verbanac K (2003) “Detection
of circulating cancer cells and protein markers in blood of breast
cancer patients by RT-PCR and ELISA,” Proceedings of the American
Association for Cancer Research 44:562, #2475.
Storey B, Pittman K, Haisch C, and Verbanac K. (2003) “E-selectin
mediates in vitro and in vivo adhesion of exogenous endothelial
cells to tumor vasculature”, Proceedings of the American
Association for Cancer Research 44:1434, #6263.
Posekany K, Pittman HK, Swansons MS, Haisch CE, Verbanac K. (2004)
“Suppression of Lewis Lung Carcinoma Tumor Development in Alpha
1,3 Galactosyltransferase Knock-Out Mice”, Anticancer Res 24(2B):
605-612.
Book Chapters
Thomas JM, Verbanac KM. Tolerance Induction: Basic Concepts and Therapeutic Approaches.
In Principles of Drug Design in Transplantation and Autoimmunity (R. Lieberman,
Ed.) Raven Press, New York, 1996.
Haisch CE, Verbanac KM. Immunity and the Immunocompromised Patient. In Physiological
Basis of Modern Surgical Care (Thomas Miller, Ed.,
third edition) Quality Medical Publishing. St. Louis, MO, in
press.
Selected National/Regional Presentations
Storey BT, Pittman HK, Min CJ, Haisch CE, Verbanac KM. (2000)
“Murine Vascular Endothelial Cells Specifically Home to Syngeneic
Lung Adenocarcinomas and Incorporate into Tumor Vasculature”,
American Association of Cancer Research Special Conference, Traverse
City, MI: Angiogenesis and Cancer Book of Abstracts, #B-45.
Verbanac KM, Min CJ, Purser SM, Swanson MS, Lo K, Albrecht J, and
Tafra L. (2000) “RT-PCR analysis for mammaglobin and
carcinoembryonic antigen detects metastases in histology-negative
lymph nodes”, Presented at the 23rd Annual San Antonio Breast Cancer
Symposium, Breast Cancer Research & Treatment 64:37, #106.
Sentara Cancer Center/Eastern Virginia Medical Center, Norfolk, VA,
Cancer Conference, “PCR Detection of Micrometastatic Breast Cancer”,
June 8, 2001.
Baptist General Hospital, Nashville Breast Center, Nashville, TN,
“PCR Detection of Micrometastatic breast cancer”, September 6, 2002.
Verbanac K, Mannie A, Min CJ, Swanson, MS, Lannin DR, Moreland M,
Tafra L. (2002) " RT-PCR Detection of Breast Cancer Metastases in
Sentinel Lymph Nodes", Dept. of Defense Breast Cancer Research
Program ERA OF HOPE, Proceedings Volume 2 :P24-32.
Tafra L, Fernandez K, Swanson M, Moreland M, Lannin D, Min CJ,
Mannie A, Verbanac K, (2002) "Indications and Contraindications for
Sentinel Node Biopsy", Dept. of Defense Breast Cancer Research
Program ERA OF HOPE, Proceedings Volume 2 :P24-33.
Verbanac KM, Mannie AE, Min CJ, Swanson MS, Lannin DR, and Tafra L.
(2002) “RT-PCR detection of metastases in sentinel nodes of breast
cancer patients”, Presented at the 25th San Antonio Breast Cancer
Symposium, Breast Cancer Research & Treatment 76:S126, #504.
Verbanac KM, Pittman HK, Storey BT, Haisch CE (2003) “In vivo
localization of exogenous endothelial cells and bone marrow cells to
damaged endothelium”, Basic Sciences Symposium of the
Transplantation Society
Invited presentation at the Veridex-sponsored pre-meeting symposium
of the San Antonio Breast Cancer Symposium New Applications of
Cellular and Molecular Technology in Breast Cancer Management, San
Antonio, TX, "PCR Detection of Nodal Metastases in Breast Cancer:
Validation and Clinical Correlation", December 2, 2003,
Podium presentation, Fifth Annual Women's Health Research Day,
University of North Carolina, Chapel Hill, NC, “PCR Detection of
Sentinel Lymph Node Metastases In Breast Cancer: Interim Report of a
Prospective Multicenter Clinical Trial”, March 17, 2004 (Refereed
abstract, no published Proceedings).
Former Students:
M.S. Students
1998 C. Justus Min, M.S. Biology. Thesis: Identification of Superior
Markers for the RT-PCR Detection of Breast Cancer micrometastases.
Medical Student, The Brody School of Medicine, East Carolina
University.
2001 Tia Coleman, M.S. Biology. Thesis: In vitro characterization of
human anti-porcine xenogeneic cellular immune responses.
Biology Instructor, Mitchell Community College, Statesville, NC.
Ph.D. Students
1999 Karla J. Posekany, Ph.D. Microbiology & Immunology. Thesis:
Evaluation of alpha 1,3 Galactosyltransferase for Cancer Gene
Therapy
2002 Bill T. Storey, PhD. Physiology. Thesis: Vascular Endothelial
Cell Homing to Sites of Neoangiogenesis
Postdoctoral Research Associate, Brown University.
Postdoctorals
1996 Brian Hoey (M.D.), Assistant Clinical Professor, Trauma &
Surgical Critical Care, University of Pennsylvania.
1998 Clint Atkinson (M.D), Vascular Surgeon, Wilmington, NC
1999 Joseph Franklin (M.D), Plastic Surgery Fellow, University of
Tennessee Memphis.
Student Awards:
2001 Bill T. Storey, Ph.D student, Recipient of Volkman Award for
Best Poster Presentation, ECU Graduate Student Research Day
Joseph Franklin, MD (PGY5), ECU,
Recipient of the Surgical Residents’ Research Day Research Award
2002 Tia Coleman Johnson, M.S. student, Recipient of Helms Student
Research Award
|
